Synthesis of 15R-PGD2: a potential DP2 receptor agonist

Bioorg Med Chem Lett. 2005 Apr 1;15(7):1873-6. doi: 10.1016/j.bmcl.2005.02.011.

Abstract

The first total synthesis of 15R-PGD(2)3 was accomplished. The approach used in this report is also an efficient method to produce 15R-PGE(2). 15R-PGD(2), a potential DP(2) receptor agonist, could be an important novel tool for defining the role of this receptor in inflammatory diseases.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Blood Platelets / drug effects*
  • Blood Platelets / metabolism
  • Cyclic AMP / metabolism*
  • Isomerism
  • Prostaglandin D2 / analogs & derivatives*
  • Prostaglandin D2 / chemical synthesis*
  • Prostaglandin D2 / pharmacology
  • Receptors, Immunologic / agonists*
  • Receptors, Immunologic / metabolism
  • Receptors, Prostaglandin / agonists*
  • Receptors, Prostaglandin / metabolism
  • Structure-Activity Relationship

Substances

  • Receptors, Immunologic
  • Receptors, Prostaglandin
  • 15-methylprostaglandin D2
  • Cyclic AMP
  • Prostaglandin D2
  • prostaglandin D2 receptor